Restylane L & Perlane L

Where can the Restylane® family of products be used?

The Restylane family can be used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds or laugh lines).

The Restylane family can also be used in other moderate to severe facial wrinkles such as lipstick lines—the area just below the nose and above the upper lip; the corners of the mouth; and marionette lines—the area that extends downward from the corners of the mouth to the jawline.

Frequently asked questions

Here are some frequently asked questions about the Restylane® family of products.

How often should I be treated?

Restylane injectable gel has been clinically proven to provide results that last up to 18 months, with only one follow-up treatment at either 4.5 or nine months. Your healthcare professional can work with you to help you establish your Restylane Regimen. Perlane injectable gel results may last up to six months after a single treatment.

When will I see results?

The Restylane family of products instantly add volume to help restore youthful contours, so you’ll see results immediately following your treatment.

How much Restylane injectable gel will I need for full correction?

Due to the individual needs of each patient, it is important to discuss your full correction with your healthcare professional. However, in a clinical study where patients received full correction for their nasolabial folds (lines from the nose to the corners of the mouth) during initial treatment in the Restylane Regimen, the average volume was 2 to 3 mL per patient.

Are there any reasons why I should not be treated with a product from the Restylane family?

Products in the Restylane family should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram-positive bacteria, or by people with previous bad allergies to drugs who have required in-hospital treatment. These products should not be used by people with bleeding disorders. Injections should not be made anywhere except the skin or just under the skin. Restylane-L and Perlane-L should not be used by people with a known allergy to lidocaine. If you are pregnant, breastfeeding, or under 18 years, you should not use products in the Restylane family.

What should I tell my healthcare professional before having a treatment with a product from the Restylane family?

You should tell your healthcare professional if you have previously suffered from facial cold sores. He or she may prescribe a medication to minimize recurrence. You should also tell him or her if you have recently used aspirin, nonsteroidal anti-inflammatory medications, St. John’s wort, or high doses of vitamin E supplements. These agents may increase bruising and bleeding at the injection site.

What are some of the common side effects?

After your treatment, you may have some swelling, redness, pain, bruising, and tenderness. This will normally last less than seven days.

The Restylane family of products includes Restylane, Restylane-L, Perlane, and Perlane-L. These products can be used individually to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Ask your healthcare professional which is right for you.

Important Safety Considerations for the Restylane Family of Products

Products in the Restylane family should not be used by people with previous bad allergies, particularly to certain microorganisms known as gram-positive bacteria, or by people with previous bad allergies to drugs who have required in-hospital treatment. These products should not be used by people with bleeding disorders. Injections should not be made anywhere except the skin or just under the skin. Restylane-L and Perlane-L should not be used by people with a known allergy to lidocaine.

Use of products in the Restylane family at the site of skin sores, pimples, rashes, hives, cysts, or infection should be postponed until healing is complete. Use of the products in these instances could delay healing or make your skin problems worse. After your treatment, you might have some swelling, redness, pain, bruising, and tenderness. This will normally last less than seven days. In rare circumstances, the doctor may inject into a blood vessel, which can damage the skin. Although rare, red or swollen small bumps may occur. If you have had facial cold sores before, an injection can cause another outbreak. To avoid bruising and bleeding, you should not use the products if you have recently used drugs that thin your blood or prevent clotting. If you are pregnant, breastfeeding, or under 18 years of age, you should not use products in the Restylane family.

Patients should be limited to 6.0 mL per treatment. The safety or effectiveness of products in the Restylane family for the treatment of anatomic regions other than nasolabial folds has not been established in controlled clinical studies.

The Restylane family of products is available only through a licensed practitioner.

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